Page locked

This page is currently locked for editing by another user. You have to wait until this user finishes editing or the lock expires.
Currently locked by: 216.73.217.8
Lock expires at: 20.04.2026 19:49 (2 min)
This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
====== Transregio-SFB 265 ======

===== Losing and Regaining Control over Drug Intake: From Trajectories to Mechanisms to Interventions =====

The main risk factors for mortality and morbidity worldwide are alcohol and tobacco consumption. While knowledge about individual factors that influence the initiation and maintenance of substance consums is increasing, there is still a lack of in-depth knowledge about modulatory factors and mechanisms that contribute to the loss and regaining of control over drug use. A better understanding of these factors and mechanisms will be critical to improving the treatment of substance use disorders (SUDs).The goal of our research consortium in TRR265 is to identify the trajectories of loss and regain of control over drug use, to investigate the underlying neurobiological and learning mechanisms, and to develop mechanism-based therapies. These goals should be achieved through 3 approaches: (I) the use of innovative mobile health tools to determine the influence of triggers, (II) in closely networked studies on humans and in animal models, the decisive mechanisms should be identified and mathematically modeled (III) based on this, interventions should be developed that specifically target these mechanisms in order to support regaining control over drug use.

Homepage: https://trr265.org


==== Important Links ====

=== Systems ===

ORSEE can be accessed via the following links:\\
[[https://orsee.zih.tu-dresden.de/trr265/public/|link for users]]\\
[[https://orsee.zih.tu-dresden.de/trr265/admin/|link for admins]]
{{page>tools:pams#"Access Link:"&noheader&nodate&nouser&}}
{{page>tools:xnat#"Access Link:"&noheader&nodate&nouser&}}
{{page>tools:redcap#"Access Link:"&noheader&nodate&nouser&}}
{{page>tools:neurotests#"Access Links:"&noheader&nodate&nouser&}}

=== Getting Access Rights for the Systems ===
{{page>start:#"Getting Access Rights:"&noheader&nodate&nouser&}}

=== Guestlogin ===
{{page>accesses:guestlogin&nodate&nouser&}}

==== Further Information about Transregio-SFB 265====

[[crc:trr:project_overview|Project Overview]]\\
[[crc:trr:mailinglists|Mailinglists]]\\
[[crc:trr:tel_conference_rooms|Telephone Conference Rooms]]\\


==== Standard Operating Procedures====

[[crc:trr:standard_operation_procedures(SOP):screening_procedure|Standard Operating Procedures (SOP): Screenig Procedure]]\\
[[crc:trr:standard_operation_procedures(SOP):Participant requests data deletion|Standard Operating Procedures (SOP): Participant requests data deletion]]

----

^ Nummer ^ Kürzel ^ Name                                        ^ Standort ^ Principal Investigators ^
| 10101  | [[projects:trr265:s01|S01]]    | Central recruitment, imaging and biobanking | Mannheim\\ Berlin\\ Dresden | Derik Hermann\\ Henrik Walter\\ Michael Marxen\\ Marcella Rietschel|
| 10102  | [[projects:trr265:s02|S02]]    | Mobile infrastructure for daily life research |Karlsruhe\\ Heidelberg\\ Mannheim|Ulrich Ebner-Priemer\\ Jan Stallkamp\\ Andreas Meyer-Lindenberg|
| 10103	 | [[projects:trr265:inf|INF]]    | Information infrastructure |Dresden| Wolfgang E. Nagel\\ Michael Smolka|
| 10104  | [[projects:trr265:z|Z]]      | Central Tasks of the Collaborative Research Center|Berlin|Andreas Heinz|
| 10111  | [[projects:trr265:a01|A01]]    | Longitudinal monitoring of triggers and modifying factors in human addiction|Potsdam\\ Mannheim\\ Berlin|Michael Rapp\\ Tobias Banaschewski\\ Andreas Heinz|
| 10112  | [[projects:trr265:a02|A02]]    | Longitudinal monitoring of cognitive control as a modifying factor of drinking behavior|Dresden|Lorenz Deserno\\ Michael Smolka|
| 10113  | [[projects:trr265:a03|A03]]    | Stress-related predictor profiles for craving and relapse in human addiction|Mannheim\\  Heidelberg\\ Dresden|Falk Kiefer\\ Jan Stallkamp\\ Clemens Kirschbaum|
| 10114  | [[projects:trr265:a04|A04]]    | Intense characterization of triggers, modifying factors and mechanisms at course transition points in human addiction|Mannheim\\ Karlsruhe\\ Berlin|Heike Tost\\ Ulrich Ebner-Priemer\\ Christine Heim|
| 10115  | [[projects:trr265:a05|A05]]    | Intensive behavioral monitoring and dynamical state transitions in animal models of addiction|Mannheim|Hamid Noori\\ Rainer Spanagel|
| 10116  | [[projects:trr265:a06|A06]]    | AI-based predictive neuro-behavioral modeling of individual trajectories in addiction|Mannheim| Daniel Durstewitz\\ Georgia Koppe|
| 10117 | [[projects:trr265:a07|A07]]    | Deep Learning for identifying subtypes in addiction based on structural MRI data|Berlin| Kerstin Ritter|
| 10118 | [[projects:trr265:a08|A08]]    | Effekte longitudinaler Sexualhormonveränderungen auf Verlust und Wiedererlangen von Kontrolle über den Alkoholkonsum: Prädiktion, Mechanismen und Behandlungstargets. |Berlin| Bernd Lenz|
| 10121  | [[projects:trr265:b01|B01]]    | Moderators of habitual versus goal-directed decision making in human addiction|Berlin\\ Dresden	| Florian Schlagenhauf\\ Tanja Endrass|
| 10122  | [[projects:trr265:b02|B02]]    | Habit formation and its relevance in alcohol addiction|Mannheim|Anita Hansson\\ Wolfgang Sommer|
| 10123  | [[projects:trr265:b03|B03]]    | Cue effects in human addiction: Pavlovian to instrumental transfer|Berlin\\ Dresden|Andreas Heinz\\ Maximilian Pilhatsch|
| 10124  | [[projects:trr265:b04|B04]]    | Cue effects and targeted neuromodulation in animal models and human addiction|Berlin|Christine Winter\\ Josef Priller|
| 10125  | [[projects:trr265:b05|B05]]    | Cognitive control of negative affect and craving for drug and alternative rewards across substance use disorders|Berlin|Henrik Walter\\ Georg Winterer|
| 10126  | [[projects:trr265:b06|B06]]    | Probing reward function during the addiction cycle by intracranial self-stimulation: the role of monoamines and alternative rewards|Mannheim|Rainer Spanagel|
| 10127  | [[projects:trr265:b07|B07]]    | Addiction-related changes in automatic S-R associations and their effects on cognitive control|Dresden|Christian Beste\\ Ann-Kathrin Stock|
| 10128  | [[projects:trr265:b08|B08]]    | Aversion discounting in behavioral control in animal models and human addiction|Mannheim|Wolfgang Sommer\\ Georgia Koppe\\ Peter Kirsch|
| 10129  | [[projects:trr265:b09|B09]]    | Computational modelling of impaired control in addiction|Dresden|Michael Smolka\\ Stefan Kiebel|
| 10131  | [[projects:trr265:c01|C01]]    | Modification of the imbalance between goal-directed and habitual behavior in human addiction|Mannheim|Sabine Vollstädt-Klein\\ Herta Flor|
| 10132  | [[projects:trr265:c02|C02]]    | Modification of Pavlovian and instrumental learning in human addiction|Berlin|Nina Romanczuk-Seiferth\\ Anne Beck|
| 10133  | [[projects:trr265:c03|C03]]    | Modification of alternative reward cue reactivity and cognitive control through physical activity in human nicotine use disorder|Berlin|Felix Bermpohl\\ Andreas Ströhle|
| 10134  | [[projects:trr265:c04|C04]]    | Modification of cue reactivity by neurofeedback and mindfulness-based intervention in human addiction|Mannheim|Peter Kirsch\\ Falk Kiefer|
| 10135  | [[projects:trr265:c05|C05]]    | Towards causal insights into contextual influences on substance use: Incorporating momentary interventions into everyday life|Berlin\\ Mannheim|Shuyan Liu\\ Markus Reichert|
| 10223  | [[projects:trr265:b03|B03 2. FP]] | Cue effects in human addiction: Pavlovian to instrumental transfer|Berlin\\ Dresden|Andreas Heinz\\ Maximilian Pilhatsch |Berlin\\ Mannheim|Shuyan Liu\\ Markus Reichert|


====== How Do I Get Support? ======

==== E-Mail ====

If you need support with an issue you may contact us at this mail address:\\
<trr265-inf@groups.tu-dresden.de> \\

**❗️ To contact us please use your offical institutional email address.**
 

----